"my newest best understanding thus far:
1. as Priscilla said ~"So, that's just your fake body" and Deneve+Helen ~"Where's it's real body?", the Destroyer has a similar body to Riful+Agatha+Ophelia. It seems that the Destroyer's real body is that mass of "hell-bodies/souls" (which maybe has come/grown from the Destroyer's huge projectiles and its tentacles, and its hell-cats' small projectiles, stealing the life forces of its hosts), that is traveling along with/inside its huge tentacled "black oil" movement/attack.
2. Also, Priscilla has seemed to have been flying right towards it (the Destroyer's real body consisting of those "hell-bodies/souls"), as seen with Priscilla standing before it, and saying ~"I'll use my full power to crush you in a single attack"
3. lastly, about Clare.
Considering that the Destroyer attacked Clare (as Helen had just left Clare on the ground as she asked if Deneve was alright, lol), destroying Clare's lower body, and then hoisting her up in the air with Clare almost dead, I don't think there's a "mutual cordial" connection between Clare and the Destroyer.
It might be possible that something might happen between the two of them, but I'm not sure at this point. It's too confusing. The Destroyer destroys Clare's lower body, nearly killing her, and now it is lifting up her in the air. It would be strange for it to have nearly killed Clare and then they bond/merge together. Though, why is the Destroyer lifting Clare up into the air? Is it merely to kill Clare, ripping her into pieces, or something else (which wouldn't make sense as it had just nearly killed Clare destrying her lower body) ?
Clare had a good relationship with Rafaela, but this Destroyer is not Rafaela (all of Rafaela LEFT the Destroyer by going inside of Clare/Clare's head, because had Rafaela stayed, she'd, well her mind, would have been killed/consumed too). So, I really don't see there being anything between Clare and the Destroyer, I mean when the Destroyer awakened, Clare was going to be killed/consumed by the Destroyer if Rafaela hadn't helped Clare break her mind-link with it. Though, the Destroyer didn't really attack Clare as she physically escaped away from it (only sending a few tentacles at her).
I don't think Claymores/HAs can survive with their entire lower body missing (unlike Awakeneds with their bodies), so I think Clare is probably dying. Now if Clare Awakened, it would regenerate herself, as she gets her Awakened body. The problem is that Clare can't Awaken. Maybe her Awakening wedge/block/limiter is now broken from the Destroyer's attack on Clare, and she now can Awaken. I mean Dauf used the Destroyer's projectile to infect himself and regenerate himself. Could Clare use the Destroyer to regenerate herself? Or are the tentacles holding Clare up, different from the projectiles? There's also the possibility of Dietrich showing up with Cynthia and Yuma, and Cynthia+Yuma can try to regenerate/save Clare too."
-HK
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*Clare is the Orochimaru (Naruto) of Claymore
*the Destroyer is now the Envy or "Father" humunculis (FMA:B) of Claymore