The younger sister of Yousuke, and thus Yotsuba's aunt. She resides in Tokyo and seldom interacts with the Koiwai family. She appears to struggle with handling children, often maintaining a serious expression and speaking bluntly.
She was initially mentioned in chapter 88 by Yotsuba's grandmother and made her first appearance in chapter 97 during Yotsuba's visit to Tokyo.
(Source: Azumanga Daioh Wiki)
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The eldest of the three Ayase sisters, Asagi lives at home while attending a nearby university. She is depicted as an attractive young woman who enjoys teasing people, especially her parents; her friend Torako describes her as a horrible person for teasin...
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The youngest Ayase sister, Ena is a few years older than Yotsuba and her most frequent playmate. She is sensible for her age and tries to be responsible by recycling and limiting her use of air conditioning. Her attempts to spare Yotsubas feelings sometim...
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The middle Ayase sister, Fuka (also romanized as Fuuka) is 16 years old and in her second year at a local high school. She is the most responsible of the sisters, and during Yotsubas first visit to her school, one student calls her "vice-president." She f...
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Yotsuba is drawn as a small girl with green hair done in four pigtails, giving her somewhat the appearance of her namesake, a four-leaf clover. She has a carefree and energetic personality, taking delight in simple matters even as she learns about all man...
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Yotsuba's adoptive father. The circumstances of her adoption are obscurehe tells Fuuka that without intending to, he found himself taking care of her while somewhere overseas, but gives no other details. Though he acknowledges Yotsuba is a bit odd,...
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A friend of Koiwai and Yotsuba, having known Koiwai since they were childhood classmates. Standing 210 centimeters (6 ft 11 in) tall, he dwarfs the other characters, especially Yotsuba. He is always called by the nickname "Jumbo," and when Fuka learns his...
Supporting
The father of the Ayase sisters is almost never at home, at least during the workweek. While his profession is not revealed, it appears consistent with the life of a salaryman. Asagi frequently teases him about his constant absence, even sometimes mention...
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The mother of the Ayase sisters, who frequently has Yotsuba over as a visitor. Unlike her daughters, she seems unfazed by Yotsubas habit of calling her "Mom." She is often irritated with Asagi, possibly because, as her husband observes, they have similar ...
Supporting
Cardbo is a "robot" that Ena and Miura make out of cardboard boxes in the fifth volume of the manga "Yotsuba&!". Hilarity ensues as Miura proceeds to fool Yotsuba into thinking that Cardbo is a real robot.(source: Wikipedia)...
