Ichigo is truly broken in this chapter.
In the HM arc against ulquiorra, even when knew and saw how Ulquiorra was more powerful than him. He didn't back down or gave up and fought on.
In the FB arc, when he lost his powers he gained to Ginjo. He despaired for a few moments. Before he gathered himself up ready to fight tooth and nail to get it back.
But here against Yhwach he lost, just as he thought it was beginning. He knows how much outclassed he was against Yhwach and there is nothing else he can do about it. This is where he lost hope, this is where he is in despair. He knows that Yhwach as said is going to absorb him and take his powers.
By Shonen rules he will be saved, probably by the dads. My guess is that they will retreat and regroup.