i feel like someone will come in at a crucial moment, maybe Kaname, and Yuuki will have to leave (or something since there's a revolution going on - still not sure if all the 'bad' vamps have been exterminated yet). it's really hard to say but the Yuuki x Zero moments are always so short and fulfilling! X,x i don't see either one dying now. i mean the whole story revolves around three characters, basically.
and it still needs to be explained what Rido meant when he said "why am I not good enough Juuri?" even though we can all know that she picked Haruka over him, there had to be something else going on, another flashback. and thus it must be his reason for targeting Yuuki. i think she resembles her mother a lot and it's obvious he sees that by the way he was talking to her in 43 (that and he's crazy, ^^).
hmmm, thinking about what i just wrote, i think Kaname will be the one to die. he is a pureblood, compared to Yuuki - even though she just 'awoke' - and the one that is more equal to Rido on a power level, or greater now since he killed Suzaku (and i'm sure Rido was the very reason he did kill her), which has still to come out. ^^ and although i like the Yuuki x Kaname pairing, i see her ending up with Zero, especially now that he's a vampire.